Protein Services

Unlock novel proteins with our expert-run expression and purification service.

We provide an end-to-end protein service for research-grade protein expression. From cloning to expression and purification, we enable our customers to unlock new potential for their research projects, without occupying their own resources. 

 

Combining the advantages of our powerful ALiCE® technology with our experience in protein production, our team of specialists will ensure you get the best results, even for the most difficult-to-express proteins.


A powerful expression system in the hands of experts


Our protein service employs a powerful eukaryotic expression system called ALiCE®. Harnessing the power of cell-free expression, ALiCE® has a strong track record producing varied protein classes1, including those with complex features such as disordered regions, transmembrane domains and kringle structures.


Our team of protein scientists excels at maximizing the potential of our expression system from cloning strategy to scalable expression and purification. With ALiCE® as our cornerstone, we boast an exceptional expression success rate of nearly 100%, along with a proven history of overcoming expression challenges encountered in other systems.

Scientist pipetting into a tube from the ALiCE cell-free protein expression kit

Our team excel at producing challenging proteins

We have produced varied proteins for our customers, many of them highly complex. These are just a few examples:

Targets

Membrane proteins and antigens, including a vaccine target with exceptionally low yields in other systems.

Complex enzymes

A therapeutic enzyme containing kringle domains and multiple glycosylation sites and disulfide bonds

Antibody variants

A varied panel of IgGs, scVs and Fabs expressed in a 96-well plate high throughput format.

We offer a no-cure-no-pay guarantee for our Feasibility Studies

Book a consultation

A flexible structure to fit your needs

Your protein service project will start with a consultation led by one of our experts. Together, we'll explore your specific protein needs and tailor the perfect solution for your project. Our modular packages feature clear deliverables and transparent pricing, allowing us to craft a customized package that aligns perfectly with your needs.


Every project begins with a feasibility study where we design optimized constructs and assess expression of your protein. We have such high confidence in our service that we offer a no-cure-no-pay guarantee for this crucial first step.


Once protein expression is established, your project gains momentum, with the first purified protein ready in as few as 10 working days from construct arrival.


Contact us for a call with one of our expters.

Protein scientists in the LenioBio labs

Cost-efficient scaling


ALiCE® eliminates the need for cell-line optimization for scaled production. Whether expressing simple or complex proteins requiring post-translational modifications or membrane integration, ALiCE® delivers consistent yields from 100 µl to 100 mL and beyond without requiring timely process optimization (Fig. 1 A and B). 


With extensive front-loading during the proof of concept and small-scale protein production phases of a project, as you progress to larger-scale protein production with us, you can begin to realize the benefits of economies of scale. With minimal optimization needed for scaling ALiCE® reactions, costs remain manageable as your protein production grows.

Interested in leveraging our expression expertise for your protein?

Book a consultation

Meet our team



Our experienced in-house team of protein experts, with over 50 years of combined expertise, will handle your project from start to finish. Covering construct design and optimization, protein expression, extraction, and purification, we ensure meticulous care at every stage. With advanced techniques and attention to detail, we deliver exceptional results that exceed expectations. Trust us to guide your protein project with expertise and precision.

  • Zulfaquar Ahmad Arfi

    Alliance Manager for Protein Characterization & Analytics

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    • Learn more about the ALiCE® expression technology

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    Do you have a specific protein that you want to express but you are unsure how?

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    References

    1. Das Gupta et. al., . 2023, J. Biotech. Bioeng.: https://doi.org/10.1002/bit.28461
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